DUAL DNA METHYLATION PATTERNS IN THE CNS REVEAL DEVELOPMENTALLY POISED CHROMATIN AND MONOALLELIC EXPRESSION OF CRITICAL GENES.

Dual DNA methylation patterns in the CNS reveal developmentally poised chromatin and monoallelic expression of critical genes.

As a first step towards discovery of genes expressed from only one allele in the CNS, we used a tiling array assay for DNA sequences that are both methylated and unmethylated (the MAUD assay).We analyzed regulatory regions of the entire mouse brain transcriptome, and found that approximately 10% of the genes assayed showed dual DNA methylation patt

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The achievement of mathematics learning in PISA, ENLACE and PLANEA in Mexican adolescents. A retrospective analysis

This article offers a historical analysis of the achievement level of mathematics learning in Mexican ninth graders.The results of the PISA, ENLACE and PLANEA tests are analyzed, with emphasis on the mathematics evaluations, given the relevance of this topic in the development of useful skills to generate technology for the 4th Industrial Revolutio

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Anti-Idiotypic mRNA Vaccine to Treat Autoimmune Disorders

The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or treatment Raw Superfoods options, except for temporary symptomatic management, leading to enormous human suffering and a monumental financial burden.The autoantibodies formed in most ADs have been identified, allowing the development of novel anti-idiotypic antibo

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Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects

Abstract Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood.Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal damage.Here we study mice with distinct defects in the proteolipid protein 1 gene that de

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